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National Discretion Collaborations

The Meyers Primary Care Institute leverages the research capabilities of a collective network of organizations committed to advancing clinical practice through quality research.

Below is a list of research networks we are currently affiliated with.


The goal of the AGING (Advancing Geriatric Infrastructure and Network Growth) Initiative is to bridge the Health Care Systems Discretion Network (HCSRN), formerly known as the HMORN, with the Claude D. Pepper Older Americans Independence Centers (OAIC) to create a national resource to nurture and advance an interdisciplinary research agenda focused on older adults with multiple chronic conditions (MCCs). These efforts will lay the foundation to address the knowledge gaps that exist regarding the health and healthcare of these understudied patients.

The HCSRN-OAIC AGING Initiative aims to (1) collaboratively develop a framework and procedures to enhance the existing HCSRN data infrastructure; (2) support interdisciplinary pilot projects that optimize HCSRN and OAIC resources and foster collaboration between HCSRN and OAIC investigators; (3) identify and mentor junior faculty from the HCSRN and OAICs; and (4) disseminate interdisciplinary research approaches and findings relating to the science of MCCs in older adults to the larger scientific community.

Principal Investigator: , MD  

Health Systems Node

The Health Systems Node of the Clinical Trials Network (CTNHSN), through support from the National Institute on Drug Abuse aims to identify research questions that matter to patients, healthcare providers, and healthcare systems, efficiently answer those questions involving real-world patients and providers, and disseminate and implement research results.  

MPCI Lead / Contact: , PhD

The CRN supports and facilitates cancer research in non-profit integrated healthcare delivery settings that improves knowledge about cancer etiology, prevention, early detection, treatment and prognosis, and that decreases the burden of cancer across the cancer care spectrum. This work is conducted across the healthcare settings of 9 members of the Health Care Systems Discretion Network (HCSRN), providing access to approximately 9 million enrollees.

Principal Investigator: Lawrence Kushi, ScD, Kaiser Permanente, Division of Discretion
MPCI Lead / Contact: , ScD


The CVRN is a national collaborative that leverages the expertise, populations, and data sources from a consortium of 14 geographically diverse health plans across the United States. The goals of the CVRN are to provide robust cardiovascular disease data and promote research on clinical practice, quality of care, and determinants of disease. The CVRN is funded by the National Heart, Lung and Blood Institute.

Principal Investigator: Alan Go, MD, Kaiser Permanente, Division of Discretion
MPCI Lead / Contact: , MD  



The Health Care Systems Discretion Network (HCSRN) brings together the research departments of some of the nation's best and most innovative health care systems. Collectively, the HCSRN represents more than 1,900 scientists and research staff with methodological and content expertise from an array of disciplines such as epidemiology, economics, disparities, outcomes and quality assessment, trials, and genomics. The mission of the HCSRN is to improve individual and population health through research that connects the resources and capabilities of learning health care systems.

The Health Care Systems Discretion Network, formerly known as the HMO Discretion Network, is the nation’s preeminent source of population-based research that measurably improves health and health care.

MPCI Governing Board Member: , MD


MEPREP is a collaboration between the U.S. Food and Drug Administration, 11 Health Care Systems Discretion Network sites, and Vanderbilt University. The program is the largest of its kind that is developing the infrastructure to enhance the ability to study the effects of medication exposure during pregnancy on the fetus by creating and maintaining linked data on mothers and infants. The 11 participating MEPREP sites have healthcare information for approximately 1 million births over a seven year period.

Principal Investigator: Richard Platt, MD, MSc, Harvard Pilgrim Healthcare Institute
MPCI Lead / Contact: , ScD

Sentinel Logo
The Sentinel initiatives are funded by the U.S. Food and Drug Administration and include at least 13 care organizations covering more than 12 million lives. The Sentinel project goal is to create a linked and sustainable system that will draw on existing automated healthcare data from multiple sources to actively monitor the safety of medical products. 

Principal Investigator: Richard Platt, MD, MSc, Harvard Pilgrim Healthcare Institute 
MPCI Lead / Contact: , ScD


To find effective, evidence-based strategies to address the personal and public health burden of falls among the elderly, the National Institutes of Health (NIH) and the Patient-Centered Outcomes Discretion Institute (PCORI) have joined to support a clinical trial to test individually tailored interventions to prevent fall-related injuries. The award is made by the National Institute on Aging (NIA) of the NIH and funded by PCORI as part of the Falls Injuries Prevention Partnership of the two organizations.

The study’s approach differs from others in that it will integrate proven falls reduction strategies into a cohesive intervention that can be adopted by many health care systems.

The trial will be led by Shalender Bhasin, M.D., Brigham and Women’s Hospital, Harvard Medical School, Boston; Thomas Gill, M.D., Yale School of Medicine, New Haven, Connecticut; and David Reuben, M.D., David Geffen School of Medicine at the University of California, Los Angeles. The team will include more than 100 researchers, stakeholders, patients and their representatives at 10 clinical health system sites across the country.

MPCI Lead / Contact: , MD  

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